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This crude material, 7-diethylamino-9-iodo-sancycline, (18 g, 295 mmol) was dissolved in anhydrous DMF (100 mL) in a 2 neck 1 L round bottom flask and placed under argon.

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The effective amount can vary depending on such factors as the size and weight of the subject, the type of illness, or the particular tetracycline compound.
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